ABSTRACT
Objective To establish a close clinical and easy to operate animal artery bypass grafting model by using vascular anastomosis wheel.Methods 15 rabbits that weighted 2.5-3.5 kg were studied.Each animal underwent an end-toend anastomosis of jugular vein and carotid artery by vascular anastomosis wheel.Carotid ultrasound and flow detection were taken immediately and 2 months after surgery respectively,as well as morphology and pathology were recorded to analyze and evaluate the intimal hyperplasia of vein graft and arteriovenous anastomotic site.Results 14 rabbits were successfully established CABG model,however 1 rabbit died of respiratory inhibition caused of excessive anesthesia.Compared with normal carotid artery,the vein bridge showed significantly lower blood flow [(50.81 ± 1.33) ml/min vs.(70.59 ± 0.68) ml/min,P ＜0.01,higher PI(2.15 ±0.07vs.1.22 ±0.04,P ＜0.01)] immediately after surgery.Compared with the vein grafts immediately after surgery,the vein grafts 2 months after surgery showed significantly lower blood flow [(27.46 ± 2.15) ml/min vs.(50.81 ± 1.33) ml/min,P ＜ 0.01].Compared with normal jugular vein,the vein grafts 2 months after surgery showed significantly higher intimal hyperplasia[(160.30 ± 1.78) μm vs.(49.06 ± 2.76) μm,P ＜ 0.01],and higher number of elastic plates(12.36 ± 0.25vs.3.21 ± 0.15,P ＜ 0.01).Conclusion The use of vascular anastomosis wheel to establish an artery bypass graft model can imitate the pathological changes of vein grafts after CABG,which can provide an ideal animal model for various researches on vein grafts.
ABSTRACT
Objective: To explore the characteristics of external iliac artery vascular complications atfer renal transplantation and the diagnosis and treatment. Methods: We reviewed the clinical data of 6 patients with of external iliac artery vascular complications atfer renal transplantation from more than 2000 renal transplantation patients in the Transplantation Center of the Third Xiangya Hospital of Central South University from 2001 to 2013, and analyzed the clinical characteristics, diagnosis and treatment. Results: hTe renal allogratf was removed in 5 of the 6 patients due to repeated external iliac arteryhemorrhage: 2 patients were replaced the external iliac artery with reversed autogenous great saphenous vein, 2 patients underwent the bilateral femoral artery bypass surgery, and 1 was repaired the external iliac artery directly. The other 1 was resected the renal allograft and the involved external iliac arteries due to fungal mass in the external iliac artery. Among the 6 patients, except 1 patient died atfer the surgery of the repair of the external iliac artery, the other 5 are all alive. Conclusion: Vascular replacement and artery bypass are effective methods for patients with external iliac artery vascular complications atfer kidney transplantation.
ABSTRACT
Se realiza un estudio en 11 pacientes escogidos al azar para cirugía vascular. 6 presentaban enfermedad renal en hemodiálisis que requerían de una fístula arteriovenosa; 2 sufrieron trauma vascular complejo y 3 presentaban enfermedad ateroesclerótica severa con daños isquémicos. Se les aplicó un procedimiento combinado de técnicas de minimo daño endotelial que disminuyeran la hiperplasia neointimal y la pérdida de permeabilidad a largo plazo. Se aplicó la toma del injerto venoso por la técnica de "no touch", anastomosis de doble anclada y llenado venoso con columna de sangre y presión propias del paciente. Los pacientes fueron seguidos por un periodo minimo de 6 meses y máximo de 10 años. Los resultados fueron alentadores con alta tasa de permebilidad en el tiempo. Creemos que la aplicación de técnicas que remeden lo mejor posible la anatomía y fisiología en el tratamiento de las enfermedades vasculares, se obtendrían resultados excelentes a largo.
This is an investigation in the camp of physilogical vascular surgery. Were included II patients, between 1996 to 2006. 6 sulfered chronic renal diseases submitted to hemodialisis, 2 with severe and complex vascular trauma and 3 suffering peripheral artery diseases with ischemic lesion. All of them were submitted to surgical techniques that diminished endothelial damage, intimal hyperplasia and permit a long time successful in vessel permeability. the patients were followed in a term of 6 month to 10 years. The vesses permeability rare was high.